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Description

10.1038/srep00667 Sci Rep

Continuing to increase the dosage beyond the 450 mcg/mL concentration to 18.75 mg/kg/h and the dosage above the 600 mcg/mL line to 25 mg/kg/h seems reasonable

Gastrointestinal conditions such as pernicious anemia (autoimmune destruction of gastric parietal cells), Crohn's disease, celiac disease, and prior gastric or ileal surgery significantly impair absorption