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10.1073/pnas.1604570113 114

Wang X, Ying T, Yuan J, Wang Y, Su X, Chen S, et al

103 Epidemiological evidence suggests that smoking tobacco is associated with a reduced risk of developing Parkinson's disease

A complex consisting of Cullin 3 (Cul3), KEAP1, and ring-box 1 (RBX1) binds to E2 ubiquitin-conjugating enzyme, and Nrf2 and Nedd8 (N8) induce a conformational change that inhibits Nrf2 ubiquitination (Reuter et al., 2010)