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It is important to mention that various studies have shown that in animal models with bleomycin-induced lung injury, vitamin B3 (niacin or nicotinamide) is highly effective in preventing lung tissue damage [7]

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This study showed that increases in plasma non-transferrin-bound iron (NTBI) and Hb resulting from stored-blood transfusions contributed to vascular disease-associated mortality through iron-enhanced Hb oxidation and subsequent tissue injury [21]