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TP53 also influences ferroptosis sensitivity through other mechanisms, such as downregulating VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1) in vitamin K metabolism [151] and inducing SAT1 (spermidine/spermine N1-acetyltransferase 1), an enzyme in polyamine catabolism that produces ROS [152]

Acute handling and transportation stress Acute stressors, such as the handling and transport of birds and sudden increases in the number of birds per cage, can cause severe neuroendocrine systemic responses

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(A summary of other types with hemorrhoid improvement potential is provided in Table 5, and chemical structures are shown in Figure 5)