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1,8-Cineole pre-treatment at 100, 200, and 400 mg/kg orally inhibited the upregulation of IL-6, TNF-, and IL-1 levels due to cerulein induction, but IL-10 level was increased by 1,8-cineole (Lima et al., 2013)

Data Animal Data In pregnant rats given twice weekly subcutaneous doses of 0.02, 0.1, and 0.5 mg/kg tirzepatide [0.03-, 0.07-, and 0.5-fold the maximum recommended human dose (MRHD) of 15 mg once weekly based on AUC] during organogenesis, increased incidences of external, visceral, and skeletal malformations, increased incidences of visceral and skeletal developmental variations, and decreased fetal weights coincided with pharmacologically-mediated reductions in maternal body weights and food consumption at 0.5 mg/kg

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