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Introduction The term oxidative stress (OS) applies when increased amounts of reactive oxygen species (ROS) surpass the antioxidant (AOX) capacity that naturally offers the protective balance ( Hence, AOX therapy to enhance fertility by protecting against the harmful effects of ROS is theoretically feasible

Symptoms in these cases may include growth retardation, intellectual disability, or acute metabolic disorders caused by metabolic stress, mainly manifested as infections, but also with systemic complications, such as epilepsy, ketoacidosis, recurrent vomiting, leukopenia, or cardiac muscle disease [11]

As with the thioldisulfide interchange, factors that enhance the stability of the leaving group will also accelerate oxidation reactions

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