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The proposed mechanism is Dexs reduction of neuroinflammation: it suppresses surgery-induced microglial activation and upregulates mitophagy in the hippocampus

Fatty acid metabolism, synthesis, and storage are affected by HS and ctl-2(ua90)II mutation One of the most important processes taking place in the peroxisomes is oxidation of very long fatty acids, products of which are stored as a reserve energy supply or shuttled to mitochondria to be fully oxidized and used to produce ATP

doi: 10.1210/jcem.84.10.6063

Ramkumar M, Rajasankar S, Gobi VV, Janakiraman U, Manivasagam T, Thenmozhi AJ, Essa MM, Chidambaram R, Chidambaram SB, Guillemin GJ (2018) Demethoxycurcumin, a natural derivative of curcumin abrogates rotenone-induced dopamine depletion and motor deficits by its antioxidative and anti-inflammatory properties in parkinsonian rats