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Serious adverse events are rare but include potential insulin resistance with prolonged use beyond 4 weeks and theoretical concerns about IGF-1s mitogenic effects, though no human data confirms increased cancer risk at research doses

To make this point clear, a method like IDOL would be advantageous only if the original marker selection contains a significant number of false positives driven by such confounders, yet as shown here, IDOL would also require a larger training set for this advantage to become apparent

10.1111/j.1365-2303.2009.00677.x Cytopathology 17 BatenburgJ

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