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Researchers should review available scientific literature, monitor study outcomes carefully, and follow proper laboratory procedures when working with peptide compounds

With the aid of CPP-mediated transport, nose-to-brain delivery can be achieved by minimizing the significant systemic exposure of administered drugs

While acute iron exposure produced minimal biochemical changes and did not sensitize cells to oxidative or ferroptotic challenges, chronic iron exposure induced ferritin upregulation, mitochondrial superoxide accumulation, suppression of GPX4 expression, elevated lipid peroxidation and loss of cellular glutathione (GSH)

doi: 10.1186/s12879-022-07859-5 66