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Consistent with their elevated SLC7A11 expression level, IRE1-null MDA-MB-231 cells also demonstrated increased cystine uptake, which can be inhibited by IRE1 reconstitution (Supplementary Fig

biochemical energy sources include, e.g., glucose or a portion thereof (e.g., glucose-6-phosphate (G6P)), pyruvate (e.g., ethyl pyruvate), NADPH, lactate or derivative thereof

Erastin can interact with VDAC2 protein to trigger mitochondrial malfunction and oxidative substance release, eventually leading to oxidative cell death, i.e., ferroptosis (53) (Figure 1)

Symptoms of methemoglobinemia result from inadequate oxygen transport