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16 Although elevated liver enzyme levels (i.e., AST and ALT levels) occur more commonly in patients with nonalcoholic steatohepatitis compared with hepatic steatosis, not all patients with nonalcoholic steatohepatitis have elevated AST or ALT levels

Data availability The datasets used during the current study are available from Abbreviations COPD: Chronic obstructive pulmonary disease PCA: Principal Component Analysis CDH5: Cadherin 5 RRM1: Ribonucleotide reductase catalytic subunit M1 SUPV3L1: Suv3 like RNA helicase KRT78: Keratin 78 CRD: Chronic respiratory disease COPD-BE: COPD co-existing with bronchiectasis COPD-MD: COPD co-existing with metabolic syndrome MPV: Mean platelet volume DEPs: Differentially expressed proteins GO: Gene Ontology KEGG: Kyoto Encyclopedia of Genes and Genomes HP: Haptoglobin HBB: Hemoglobin subunit beta VCL: Vinculin HBA1: Hemoglobin subunit alpha 1 CA1/2: Carbonic anhydrase 1/2 SOD1: Superoxide dismutase 1 FGA: Fibrinogen alpha chain PRDX2: Peroxiredoxin 2 ALDOA: Aldolase, fructose-bisphosphate A TNC: Tenascin C CAT: Catalase PRM: Parallel Reaction Monitoring B4GAT1: Beta-1,4-glucuronyltransferase 1 GNPTG: N -Acetylglucosamine-1-phosphate transferase subunit gamma ADAMTSL4: ADAMTS like 4 CFP: Complement factor properdin EXTL2: Exostosin like glycosyltransferase 2 SAA1: Serum amyloid A1 CRP: C-reactive protein ORM1/2: Orosomucoid 1/2 DEMs: Differentially expressed metabolites WGCNA: Weighted gene co-expression network analysis BALF: Bronchoalveolar lavage fluid RAB26: Member RAS oncogene family SERPINA1: Serpin family A member 1 GOLD: Global Initiative for Obstructive Lung Disease PBMCs: Peripheral blood mononuclear cells References Barnes PJ

Personalized treatment approaches based on individual gut microbiota profiles represent a promising avenue for future research