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Targeting the USP7-PRMT6 epigenetic axis overcomes chemoresistance in breast cancer by coordinating H3R2me2a deposition and RNF168 methylation for DNA repair and ferroptosis blockade

MSCs primarily engage in immunomodulatory activities through cell-to-cell interactions with immune cells, including T cells, B cells, natural killer (NK) cells, macrophages, monocytes, dendritic cells (DCs), and neutrophils (252)

Originally investigated by researchers for its profound cytoprotective effects on the gastrointestinal mucosaspecifically in the healing of gastric ulcers and inflammatory bowel diseasethe therapeutic potential of BPC-157 has since expanded dramatically into the realms of severe musculoskeletal repair, soft tissue regeneration, and advanced neuroprotection

Zhang Y, Xu Y, Zhang L, Chen Y, Wu T, Liu R, Sui W, Zhu Q, Zhang M (2022) Licorice extract ameliorates hyperglycemia through reshaping gut microbiota structure and inhibiting TLR4/NF-B signaling pathway in type 2 diabetic mice