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Applying retinoids, AHAs, BHAs, or strong vitamin C during this window introduces irritants directly into a partially open dermal layer, which produces a much stronger irritation response than the same actives applied to intact skin

Patients who experience significant side effects at any dose can remain at that dose longer (6-8 weeks) before escalating, or step back to the previous dose temporarily before attempting escalation again

The peak-load price ($/MWh) for an on-peak hour H is defined by energy economists to be the price that equates marginal energy supplier profit ($/MWh) for H to supplier capacity cost c ($/MWh) for H, where c denotes the amortized fixed cost of energy production per hour ($/h) per unit of capacity (MW)

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