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The significant increase in m6A-modified genes may also lead to the conversion of microglia to the M1 phenotype and involvement in inflammatory responses (Li Q

The metabolite-driven approach relies on empirical data showing that specific exogenous nutrient metabolites potentiate the lethal effects of known antibiotic drugs 9

miR-93 agomir reduces cytokine expression, microglial activation, inflammation, and RGCs loss, by targeting STAT3 to exert its effect on RGC death (Wang et al., 2021)

If the drug does not readily cross lipid membranes, it will be confined mainly to the extracellular fluid and a plasma sample therefore will have a high drug concentration