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The formula commonly applied in veterinary pharmacology research uses the equation: canine dose (mg/kg) = rodent dose (mg/kg) (rodent Km / canine Km), where Km values reflect species-specific BSA-to-weight ratios

The clinical dosage range spans 2.510 mg per subcutaneous injection, titrated over 4 weeks before reaching a maintenance dose of 510 mg, five times weekly