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This release can occur through different mechanisms, such as nanoparticle dissolutionan instability that arises under specific pH conditions, typically at lower pH, leading to matrix dissolutionand polymer swelling, a process in which nanoparticles swell at certain pH conditions, both ultimately resulting in drug release (Karimi et al., 2016)

Intranasal delivery extends the effective CNS half life because the peptide is transported directly along olfactory and trigeminal nerve pathways into cerebrospinal fluid and hippocampal interstitial space, bypassing systemic circulation and hepatic metabolism

IV drips allow clinicians to monitor the infusion and adjust dosing with more precision

doi: 10.15252/embj.2019101982 85 WaaijerMECGunnDAAdamsPDPawlikowskiJSGriffithsCEMvan HeemstDet al