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The Icahn School of Medicine at Mount Sinai (to which J.W.M

DOI: 10.1016/j.smed.2019.04.019.

Redox signaling is based on reversible oxidative posttranslational modifications such as thiol-disulfide switches, S-glutathionylation, and S-nitrosylation

This degradation, in turn, allows NF-B activity to increase, resulting in increased transcription of pro-inflammatory genes, including TNF-, IL-1, IL-6, and inducible nitric oxide synthase (iNOS) (Morgan and Liu, 2011)