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In the present analysis, confounding environmental factors including viral hepatitis, HIV infection and alcohol consumption were excluded, but other factors including age, sex and BMI were included, which may have thus resulted in an inaccurate association

These changes indicate increased oxidative stress and insufficient antioxidant defense mechanisms

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Administration of JZP541 induced a dose-dependent response in gene expression within the frontal cortex, with the 10 mg/kg dose altering the expression of only seven genes, whereas the 100 mg/kg dose affected more than 1300 genes