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The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue

Ghreishi Rad, S

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 189,00 per year only 15,75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

Moreover, central inflammatory signals can activate mitogen-activated protein kinase (MAPK), which in turn increases the number and activity of presynaptic reuptake pumps, resulting in reduced synaptic availability of monoamine neurotransmitters, including norepinephrine (NE) (47, 48)