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Copper is only required in trace amounts by the body, and too much copper buildup could theoretically cause nausea, abdominal pain, tiredness, liver damage, and neurological effects

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Therefore, the severe interstitial edema, more expressed in white than in gray mater, and severe neuron loss in hippocampal neurons, neurons of dentate nucleus, Purkinje cells and other cerebellar nuclei and less severe damage in the pons, the mesencephalon and lateral geniculate body could be a specific paracetamol effect and these territories could be involved in the occurrence of maximal paracetamol induced seizures

The next section examines five such botanicals, berberine, ashwagandha (Withania somnifera), Scutellaria baicalensis, Salvia miltiorrhiza, and additional Withania withanolides, in the context of mechanistic inhibition of the TGF-1 axis