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Despite infusion reactions being one of the most common adverse effects of CD38 inhibitors, existing clinical trials have demonstrated excellent safety [109, 110]

Kynurenine is subsequently converted to NAD + in a chain of reactions with the rate-limiting step by quinolinic phosphoribosyltransferase (QPRT), which converts quinolinic acid into nicotinic acid mononucleotide (NAMN) 26 , finally entering the PreissHandler pathway