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Compared with the wild-type (WT) GPCR activation, the common pharmacological mechanisms of activating and inactivating mutations lie in three aspects: (1) Mutations transform micro-switch cascades within the receptors and induce active/inactive conformations, thus altering the constitutive activity of GPCRs and affecting the recruitment of downstream effectors

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had a dermabrasion and/or ablative laser treatment on their neck within the previous six months