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2022, 6160010 (2022), Abstract Developing dietary curcumin mono-carbonyl piperidinone analogs as Nrf2-dependent cytoprotectors against oxidative damage: Structure-activity relationship and mechanisms: X.F

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IAC-S010759(OPi) has same functional backbone but has been attenuated conduction (Vashisht Gopal et al., 2019), a directed CI inhibitor, was shown to significantly inhibit the growth of melanoma models with multiple MAPKi resistant BRAF mutation in vivo at tolerated doses, and strongly inhibited proliferation and induced apoptosis in OXPHOS-dependent brain cancer and acute myeloid leukemia (AML) models