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Graves orbitopathy (GO) is the most prominent and common extrathyroidal manifestation of GD, characterized by the production and accumulation of glycosaminoglycans (especially hyaluronic acid) in the retrobulbar and periorbital tissues causing protrusion of the eyeball and restriction of ocular muscle movement ( Table 1

despite a significant association of plasma UA with PD incidence, the genetic association with PD was not apparent 28

Discussion To date, the replacement of -cells by pancreas and pancreatic islet transplantation are the only concrete alternatives for re-establishing the endogenous insulin secretion in patients with type 1 diabetes

T., and Dang, C