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For athletes specifically, how to reduce cramps when running comes down to race-pace hydration, pre-race sodium loading, consistent training (not sudden volume spikes), and post-run stretching of the calves, hamstrings, and hip flexors

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However, the actions of MTX on folic acid are not related to its ability to reduce inflammation and joint damage at the low doses used in treating rheumatoid arthritis, says rheumatologist Gabby Schmajuk, MD, MS, associate professor of medicine at the University of California San Francisco