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Therefore, studying phenological changes in amphibians is a critical tool for understanding the impacts of climate change on life history strategies and population sustainability

Severe cases progressing to liver failure may exhibit progressive jaundice, petechiae, ecchymosis, ascites, peritoneal infections, and hepatic encephalopathy

These observations were consistent with our results, where Klotho administration inhibited FOXO3 phosphorylation and its subsequent ubiquitination and degradation

Conclusion: Hepatic stellate cells avoided necroptosis due to a lack of MLKL phosphorylation and oligomerization and activated via autophagosome and NF-B pathways