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Introduction Systemic lupus erythematosus (SLE) is a complicated autoimmune disease characterized by various immune defects and chronic inflammation affecting multiple tissues and organs, and with a remarkably high morbidity and mortality rate ( Although the exact mechanisms of autoimmune responses in SLE are not well understood, rapid development of technologies offers opportunities to examine various aspects of the diseases, providing novel insights into their pathogenesis

Recent studies have shown that treatment of patients with advanced liver cancer with sorafenib mediating retinoblastoma protein can significantly improve the sensitivity of liver cancer cell death to iron and sensitize patients to the anticancer effects of sorafenib (79)

Recently, De Souza et al