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Preclinical studies report approximately 1.6 increases in intracellular NAD+ following NNMT inhibition in adipocyte models

A randomised controlled trial published in Clinical Infectious Diseases demonstrated that Thymosin Alpha-1 treatment in severe COVID-19 patients reduced 28-day mortality by 30% compared to standard care alone.17 While this was acute disease, not long COVID, it confirms the biological plausibility of the immune mechanism

In a rat model of depression, the astrocytic potassium channel (K ir 4.1) drives neuronal bursts in the lateral habenula (LHb), which suggests that it may serve an important function in astrocyte-neuron communication in depression (Cui et al., 2018