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10.1016/j.molmet.2020.01.002 97

Michel P, Pandya AG

identified eight novel potential GPX4 activators and determined that compound 1d4 is the most potent allosteric activator of GPX4, effectively inhibiting ferroptosis in HT-1080 fibrosarcoma cells [328]

While the peak for GSH (2.98 min) gradually decreased, the signal corresponding to GSSG increased (4.37 min), indicative of the expected chemical transformation (Fig