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In the other direction, the brain may exert an influence on the gut, either via the autonomic and enteric nervous systems (downwards black arrows in Figure 2 ), or via activation of the Hypothalamus-Pituitary-Adrenal (HPA) axis (downwards red arrows in Figure 2 ), which will be examined in detail later

Response: As we discussed in prior rulemaking, we continue to believe it would be inappropriate for any product to have an applicable percentage of 100 percent, as stated in the CY 2024 PFS final rule (88 FR 79053), or to expand the list of exclusions described in section 1847A(h)(8)(B) of the Act by proposing an increased applicable percentage of 100 percent to drugs not excluded in such section