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The relation between surviving cells and treatments concentration is plotted to get the survival curve of each tumor cell line after treatment with the specified compound

Peripheral blood samples were analyzed for concentrations of metalloproteinase (MMP)-9, tissue inhibitors of MMP (TIMP)-1,2, and myeloperoxidase (MPO)

Since deletion of IL-1 reduces steatohepatitis, and fibrosis in mice fed a NASH-inducing diet (418), further investigation on the effects of canakinumab in human NASH are warranted