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However, such an approach is likely beneficial for patients receiving high doses of metformin over an extended period

It has also been shown to influence lipid metabolism enzyme activity, including hormone-sensitive lipase and lipoprotein lipase, and to modulate adipogenic transcription factor expression in adipocyte differentiation models

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Materials and methods Study participants Men and women aged between 18 and 80 years diagnosed with NAFLD by ultrasound who had an increased serum level of alanine transaminase (ALT) were recruited from the Gastroenterology Clinic and Radiology Center of Shahid Beheshti Hospital, Kashan University of Medical Sciences