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However, the consistent clinical failures of these reductionist approaches have prompted a paradigm shift toward multi-target interventions designed to concurrently modulate multiple facets of neurodegeneration

There was no change in Thymine-DNA glycosylase (Tdg) mRNA level

The confirmed harms were a small increase in liver enzymes, a roughly 1% incidence of muscle symptoms, and a modest rise in blood sugar in patients already near the diabetes threshold