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Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

J., Bhutani, J., & OKeefe, J

Preclinical models provide stronger internal validity, showing convergent improvements in oxidativeinflammatory balance, TGFdriven fibrosis, neuromuscular plasticity, and Bax/Bcl2mediated apoptotic control when polyphenols are paired with structured training or rehabilitation, but translational certainty to human oncology remains moderate due to species, dosing, and diseasemodel differences

The observation focused on tail motor functions, assessing their loss on a scale of 1-5, where 1 indicates complete loss of function and 5 normal, preserved tail functions