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The important connection between folate and successful pregnancy are well documented, and many women with a history of infertility and miscarriages have found an important missing link in taking the MTHFR blood test

Abbreviations ATF4: Activating transcription factor 4 CHAC1: GSH-specific -glutamyl cyclotransferase 1 ER: Endoplasmic reticulum GGC: -Glutamyl-cysteine GSH: Glutathione GSIS: Glucose-stimulated insulin secretion HFD: High-fat diet KO: Knockout KRB: Krebs-Ringer bicarbonate buffer LPS: Lipopolysaccharide NMDA: N -methyl-d-aspartate qPCR: Quantitative real-time PCR ROS: Reactive oxygen species Sxc: System x c - WT: Wild-type References Maechler P (2017) Glutamate pathways of the beta-cell and the control of insulin secretion