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However, this experiment was conducted in cultured neurons and, in a physiological context, the CB 1 receptor is not easily able to enhance glutamate release because the inhibition of cAMP also suppresses the key active zone proteins, like Munc-13 and RIM, necessary for vesicle docking

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As specified in the United Kingdom clinical guidelines for motor neuron disease, the usual care comprises medications and treatments such as non-invasive ventilation, physiotherapy and gastrostomy, and access to other hospital-based and community-based services, including equipment and adaptations, orthotics, respiratory, gastroenterology, clinical psychology, neuropsychology, and counselling, as well as social care services