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Participants returned every 3 months for reassessment

These include the nuclear factor-B (NF-B) pathway and the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) pathway, which are commonly associated with stress and inflammatory responses (Jiang et al., 2022

In addition, carbonic anhydrase generates additional H + by catalyzing the excessive CO 2 hydration produced by the pentose phosphate pathway in tumor cells, which also contributes to the formation of acidic TME (50)