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18 Prevention Because of potential interactions from prolonged medication use, physicians should consider screening patients for vitamin B 12 deficiency if they have been taking proton pump inhibitors or H 2 blockers for more than 12 months, or metformin for more than four months

Representative images of at least three independent replicated experiments are shown

Excess iron, due to its catalysis of one electron redox chemistry, plays a key role in the formation of toxic oxygen radicals

In a rat model simulating tyrosinemia type II through chronic L-tyrosine administration, NAC co-treatment effectively prevented the decline in ChAT activity in the cerebral cortex and partially reversed the increase in AChE activity in the hippocampus and striatum [120]