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10.2147/DDDT.S148868 347 ZhuZ.LiQ.XuC.ZhaoJ.LiS.WangY.et al (2020)

AtaideJAdeCarvalhoNMRebeloMAChaudMVGrottoDGerenuttiMet al

Given the brains unique susceptibility to proteotoxic stress, owing to its post-mitotic neuronal population, high metabolic demand, and reliance on precise proteome regulation, UPS integrity is indispensable for neuronal survival