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Combined supplementation can have a synergistic effect in improving thyroid function and reducing inflammation in autoimmune thyroid diseases [12]

Many of the processes that drive the glycolytic switch in M1 macrophages are downregulated in M2 macrophages (Figure 4)

Ferrostatin-1 significantly mitigated these effects suggesting that lipid peroxidation drives this state

Clinical studies have shown that the use of doses of up to 1,000 mg/day for several months did not adversely affect hematological parameters, liver and kidney function, or serum electrolyte levels, indicating that it is well tolerated in humans (Okamoto, 2005