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This essentialfunction is underscored by the existence of mutants with a high-carbon-requirement (HCR) phenotype,which are unable to grow under ambient CO 2 conditions but remain viable at elevatedCO 2 levels (Somerville, 2001)

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While the question of the musical expression of emotion has a long history of investigation, including in PNAS (6), and the 1990s psychophysiological strand of research had already established that musical pleasure could activate the autonomic nervous system (7), the authors' demonstration of the implication of the reward system in musical emotions was taken as inaugural proof that these were veridical emotions whose study has full legitimacy to inform the neurobiology of our everyday cognitive, social, and affective functions (8)