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This is particularly important in high-energy demanding organs such as the heart and brain, where oxidative stress can lead to severe dysfunction if not adequately managed

Some bacteria, such as "Cyanobacteria" and Pseudomonadota, can biosynthesize glutathione

Glutathione biosynthesis is facilitated by a rate-limiting enzyme, glutamate-cysteine ligase (GCL), which consists of a catalytic subunit (GCLC) and a modifier subunit (GCLM)

489 In families affected by XLID, a number of loss-of-function mutations were found in the GDI1 gene, 490 which encodes a cytosolic protein GDI, the RAB GDP dissociation inhibitor, involved in the control of the guanosine diphosphate (GDP)-bound form of the brain RAB GTPases 491,492 and regulates vesicle dynamics