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Herein we summarize the efforts the last three decades to transform the hexapeptide into more drug-like peptidemimetics acting at its receptor(s)

The likely mechanism by which A 142 induces HSV-1 aggregation is by the shared sequence homology of an aggregation-prone region of the HSV-1 glycoprotein B to which A 142 can bind and induce aggregation (Cribbs et al., 2000)

Critical note: use separate vials and syringes for each peptide since mixing peptides in the same syringe risks stability issues

Below is an example of introducing non natural amino acids: R1-NH 2 + C 10 H 10 N 2 O 2 -OH C 10 H 10 N 2 O 2 -R1 + H 2 O It should be noted that due to the different structures of the amino acid side chain group R1, the reaction conditions, solvents, reagents, etc