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IGF1, which is mainly expressed in the hepatic tissue, can directly inhibit GH secretion in the somatotrophs of fish (18, 50, 96, 97), birds (98, 99) and mammals (28, 87, 92, 100), through a longloop negative feedback (by acting on the pituitary and/or on GHRH in the brain, Figure 1 ), but also indirectly by enhancing the hypothalamic release of somatostatin (5)

Mossmann D, Park S, Hall MN

Therefore, increased iron uptake and decreased iron output can lead to iron overload and thus ferroptosis

For Muslim consumers in particular, dietary restrictions based on Islamic law play an essential role in their product choices