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Despite mixed clinical outcomes, these formulations highlight the ongoing efforts and challenges in optimising nanocarrier-based platinum drug delivery systems

10.1016/j.physbeh.2017.09.024 Physiol

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They found that the GO-PEG hybrid exhibited high drug loading and more release at acidic pH (5.8) because of two kinds of possible H-bonding between the drug and carrier, whereas at neutral pH (7.4), four kinds of H-bonding existed between the drug and carrier