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This reduction is often caused by oncogenic mutations in metabolic enzymes like succinate dehydrogenase (SDH), fumarase (FH), and isocitrate dehydrogenase (IDH1/2), leading to the accumulation of metabolites such as fumarate, succinate, and 2-hydroxyglutarate (2HG), respectively (reviewed in refs

However, in contrast, several reports have presented that a high dose of lithium could induce irreversible neurotoxicity effects 22

Feasibility of shortening intravenous antibiotic therapy for bronchiectasis based on bacterial load: A proof-of-concept randomised controlled trial

This complex amplifies iNOS expression alongside other transcription factors ( Figure 4 )