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Description

Hall B, Marini F, Andreeff M

Abstract Nuclear factor erythroid 2-related factor 2 (NRF2) is a stress responsive transcription factor that is mutationally activated in a subset (~25%) of clinically-aggressive non-small cell lung cancers (NSCLC)

NNMT depletes cells of NAD+, a crucial coenzyme required for mitochondrial function and energy production

We hope that in the future, more researchers will focus on more basic research on HO-1 in DN, including its expression regulation, mechanism of action, and interaction with other molecules