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Proc Natl Acad Sci U S A , 119 (17), e2121816119

Flavonoids have important physiological functions in plants

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2396-C WESTERN DIET DAMPENS T REGULATORY CELL FUNCTION TO FUEL HEPATIC INFLAMMATION IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE Sudrishti Chaudhary 1 , Ravi Rai 1 , Pabitra Pal 1 , Dana Tedesco 2 , Aatur Singhi 3 , Satdarshan (Paul) Monga 1 , Arash Grakoui 2 , Smita Iyer 1 and Reben Raeman 1 , (1)University of Pittsburgh, (2)Emory University School of Medicine, (3)University of Pittsburgh Medical Center Background: The immunosuppressive T regulatory cells (Tregs) regulate immune responses and maintain immune homeostasis, yet their functions in metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis remains controversial