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Description

NRF2 is inactivated by Kelch-like ECH-associated protein (KEAP)1, a protein that binds it and acts as a substrate adaptor for the Cullin-3-containing E3 (CUL3-RBX1) ubiquitin ligase, which ubiquitinizes NRF2 and promotes its degradation in the proteasome 45

CrossRef cell recovery revisited: Is prediabetes remission driven by insulin sensitivity or cell function

Acta 349 , 4552 (2004)

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