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Online Mendelian Inheritance in Man, OMIM (2023)

Recently, a human gene mutation of PAPP-A2, a circulating and tissue protease with IGFBP-5 (and to some extent IGFBP-3) as its primary substrate (Gaudamauskes et al), was demonstrated to have a marked growth phenotype involving fetal and post-natal growth retardation in children in a consanguineous family (43)

(2 ) :

Discussion Despite decades of research into anthelmintic resistance, most current knowledge centers around a set of well-characterized target-site mechanisms, such as mutations in -tubulin, ligand-gated chloride channels, or nicotinic acetylcholine receptors [13]